Balbekin, Nikolay S., Quentin Cassar, Olga A. Smolyanskaya, Maksim S. Kulya, Nikolay V. Petrov, Gaetan MacGrogan, Jean-Paul Guillet, Patrick Mounaix, and Valery V. Tuchin. "Terahertz pulse time-domain holography method for phase imaging of breast tissue." In Quantitative Phase Imaging V, vol. 10887, p. 108870G. International Society for Optics and Photonics, 2019.
Abstract
Pulse holographic imaging along with time-domain spectroscopy scan and
tomographic techniques are of great interest. Since the advantages of
holography are the lack of focusing optics and high spatial resolution, and,
comparing with tomography, less computation cost for numerical reconstruction,
this technique is preferable for the analysis of thin histological samples. In
this work we have created the experimental scheme that involves measurement of
diffraction pattern of the collimated THz pulse field spatial distribution at
some distance behind the object in the time-domain mode, thus allowing
reconstruction of amplitude and phase distribution at the object plane by
numerical backpropagation of the wavefront in the spectral domain. In our
experiment, we used a breast biopsy sample containing cancer tissues, we also
performed numerical simulations accounting for experimental conditions to
confirm the conceptual applicability of the reconstruction method.
BREAST TISSUE PROBING 3.1 Material & Methods A commercially
available TeraPulse4000 (TeraView Ltd,
Cambridge, UK) configured in reflection geometry by the means of external
added optics was used to probe freshly excised breast tissues …
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