Cassar, Quentin, Amel Al-Ibadi, Laven Mavarani, Philipp Hillger, Janusz Grzyb, Gaëtan MacGrogan, Thomas Zimmer, Ullrich R. Pfeiffer, Jean-Paul Guillet, and Patrick Mounaix. "Pilot study of freshly excised breast tissue response in the 300–600 GHz range." Biomedical Optics Express 9, no. 7 (2018): 2930-2942.
The failure to accurately define tumor margins during breast conserving surgery
(BCS) results in a 20% re-excision rate. The present paper reports the investigation to
evaluate the potential of terahertz imaging for breast tissue recognition within the underexplored
300–600 GHz range. Such a frequency window matches new BiCMOS technology
capabilities and thus opens up the opportunity for near-field terahertz imaging using these
devices. To assess the efficacy of this frequency band, data from 16 freshly excised breast
tissue samples were collected and analyzed directly after excision. Complex refractive indices
have been extracted over the as-mentioned frequency band, and amplitude frequency images
show some contrast between tissue types. Principal component analysis (PCA) has also been
applied to the data in an attempt to automate tissue classification. Our observations suggest
that the dielectric response could potentially provide contrast for breast tissue recognition
within the 300–600 GHz range. These results open the way for silicon-based terahertz
subwavelength near field imager design, efficient up to 600 GHz to address ex vivo lifescience
applications.
… interface delimitation tool. 2. Methods 2.1 Acquisition set-up
A commercially available TeraPulse 4000 (Teraview Ltd, Cambridge, UK), with a modified reflection
geometry shown in Fig. 1, was used in this study. THz pulses are …
for full paper see https://www.osapublishing.org/DirectPDFAccess/C0FACBEC-D24C-2BB6-FE19B240275EDEC2_390258/boe-9-7-2930.pdf?da=1&id=390258&seq=0&mobile=no
Also see: teraview.com
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