Classification of terahertz-pulsed imaging data from excised breast tissue

Anthony J. Fitzgerald and Vincent P. Wallace

University of Western Australia, School of Physics, Crawley 6009, Australia

Sarah Pinder and Anand D Purushotham

King’s College London, Section of Research Oncology, Guy’s Hospital, London SE1 9RT, United Kingdom

Padraig O’Kelly and Philip C. Ashworth

TeraView Ltd., Platinum Building, John’s Innovation Park, Cowley Road, Cambridge, CB4 0WS, United Kingdom

University of Cambridge, Semiconductor Physics Group, Cavendish Laboratory, Cambridge, CB3 0HE, United Kingdom

J. Biomed. Opt. 17, 016005 (Feb 06, 2012)

We investigate the efficacy of using data reduction techniques to aid classification of terahertz (THz) pulse data obtained from tumor and normal breast tissue. Fifty-one samples were studied from patients undergoing breast surgery at Addenbrooke’s Hospital in Cambridge and Guy’s Hospital in London .....

for more information click here

or here http://dx.doi.org/10.1117/1.JBO.17.1.016005

... Data Acquisition Data from all breast specimens were collected using TPIscan (TeraView Ltd.,
Cambridge, UK). ...

For TeraView's range of products see http://www.teraview.com/products/index.html

For more information information click here 

New Centre for Terahertz Science and Engineering (CTSE)

Welcome to the Centre for Terahertz Science and Engineering (CTSE), established in February 2012. This Imperial College London centre is in partnership with the UK's RAL Space Millimetre Wave Technology Group and is located within the Faculty of Engineering at Imperial College London. Our main goal is to become the leading UK platform for terahertz (THz) science and engineering, dedicated to the following:

• Research and development of new materials and their electromagnetic characterization for THz applications
• Research and development of passive components and active devices, based on advanced functional materials and micro/nano-fabrication processing technologies
• Exploration of new applications in the areas of telecommunication and electromagnetic sensing for bioengineering, security and defence applications
• Interdisciplinary education and training in electromagnetic material characterization, millimetre-wave and terahertz engineering, device/circuit simulation and metrology.

In addition, CTSE provides:

• A forum to stimulate more formal inter-departmental/faculty collaboration at Imperial College London, ensuring cross-fertilisation between different fields of research.
• A joint facility for external collaboration with academia, research laboratories, government agencies and industry.
• A forum for the exchange of ideas between researchers, as well as a focal point for the exchange of expertise and resources.
• A venue for educational teaching activities (e.g. joint masters degree courses and Summer Schools).

TeraView at the International Forum on Terahertz Spectroscopy and Imaging - March 2012

Denken Sie daran, Ihr Treffen mit David Lowe (david.lowe @teraview.com) zu buchen bei der "International Forum on Terahertz Spectroscopy and Imaging" am Fraunhofer-Zentrum, Kaiserslautern(Deutschland) nächste Woche.

Remember to book your meeting with David Lowe (david.lowe@teraview.com) at the "International Forum on Terahertz Spectroscopy and Imaging" at Fraunhofer-Zentrum, Kaiserlautern (Germany) next week.


To see TeraView's products visit
http://www.teraview.com/products/index.html

3rd EOS Topical Meeting on Terahertz Science & Technology (TST 2012)

Location: 

 Kaiserstejnsky Palace, Prague, Czech Republic

Duration: 

 17 June 2012 - 20 June 2012

Submission Timeframe: 

 15 December 2011 - 24 February 2012

General Chair(s): 

• Petr Kužel - Institute of Physics of the ASCR / Czech Republic
• Peter Uhd Jepsen - Technical University of Denmark / Denmark

Program Committee: 

• Richard Averitt - Boston University / United States
• Jean-Louis Coutaz - Université de Savoie / France
• Guilhem Gallot - Ecole Polytechnique / FR
• Rupert Huber - Universität Konstanz / Germany
• Michael Johnston - University of Oxford / United Kingdom
• Martin Koch - Philipps-Universitaet Marburg / Germany
• Chiko Otani - Riken Sendai / Japan
• Paul C.M. Planken - Delft University of Technology / Netherlands
• Masayoshi Tonouchi - Osaka University / Japan
• Alessandro Tredicucci - NEST, CNR-NANO / Italy
• Karl Unterrainer - Technische Universität Wien / Austria

Topics

• Emission of THz radiation (QCLs, HEMTs, FELs, synchrotrons, nonlinear optics etc.)
• Detection of THz radiation (quantum dots, single photon detectors, time-gated, HEMTs etc.)
• THz integrated optics, waveguiding, plasmonics, metamaterials, photonic crystals
• Interaction of THz radiation with matter (dielectrics, semiconductors, nanostructured materials, liquid-state dynamics, chemistry, biology, ultrafast spectroscopy etc.)
• Nonlinear phenomena induced by THz radiation
• THz far-field and near-field imaging, THz microscopy and microspectroscopy
• Remote sensing of gases and chemical / biological agents
• THz applications (security, telecom, remote detection etc.)

Keynote Speaker

• Xi-Cheng Zhang, University of Rochester (US)
   

Masterclass Speakers

• Edmund H. Linfield, University of Leeds (GB)
• Keith A. Nelson, Massachusetts Institute of Technology (US)
  

Invited Speakers 

• Dave Cooke, McGill University (CA)
• Kodo Kawase, Nagoya University (JP)
• Junichiro Kono, Rice University (US)
• Oleg Mitrofanov, University College London (GB)
• Hynek Nemec, Academy of Sciences of the Czech Republic (CZ)
• Alexej Pashkin, University of Konstanz (DE)
• Marco Rahm, Technical University of Kaiserslautern (DE)
• Giacomo Scalari, ETH Zurich (CH)
• Miriam Vitiello, National Research Council (IT)

Venue

Prague, the capital of the Czech Republic, is a most valuable historical city reserve. In 1992, the historical core of the city covering 866 hectares was listed in the UNESCO World Cultural and Natural Heritage Register. Prague represents a unique collection of historical monuments dominated by the Prague Castle which towers high above the city (www.praguewelcome.cz).

TST 2012 will take place at Kaiserstejnsky Palace which is located in the Prague Lesser Town and has been hosting events for more than three centuries.  

Its total reconstruction began under the architects Zdeněk Pokorný and Jaroslav Bělský in 1977, and it was registered a UNESCO heritage site in 1981. Restitution procedures were completed and the palace returned to its original owners in 1997. 

For more information see

http://www.myeos.org/events/tst2012

3D-Tablettenprüfung mittels Terahertz

(Terahertz imaging note in German)

23.02.2012

Schichtaufbau und Integrität von Tabletten lassen sich mit THz-Strahlung berührungslos und schnell prüfen. Die Technik ist nun auch als Auftragsanalytik für Pharmaunternehmen verfügbar.

In Ergänzung zu seiner Laboreinrichtung in Cambridge bietet die auf THz-Strahlung spezialisierte britische TeraView Ltd. jetzt auch in Dayton, Ohio, USA, am Institute for the Development and Commercialization of Advanced Sensor Technology, IDCAST, pharmazeutischen Unternehmen Zugang zu einem Echtzeit-Messverfahren für den Schichtaufbau von Tabletten. Das Verfahren erfasst mithilfe gepulster THz-Strahlung (Terahertz pulsed imaging, TPI) von 2 bis 120 cm-1 zerstörungsfrei und direkt in der laufenden Produktion die Varianz der Schichtdicken, Partikelagglomerationen und Dichteschwankungen. Auch Prozesse wie das Eindringen von Wasser oder Luft, Probleme beim Aushärten oder mangelnde Integrität der Schichten können damit lokalisiert werden.
In enger Zusammenarbeit mit den Kunden wird anhand von THz-Messdaten die Entwicklung neuer Produkte oder technischer Fertigungsanlagen begleitet sowie zur Lösung von Qualitätsproblemen beigetragen. Der Service umfasst den Verleih des Messsystems TPI imaga 2000 sowie eine enge Betreuung der Untersuchungen. Damit sparen Kunden die Investition in eigene Prüfanlagen.
Auch aus anderen Anwendungsbereichen erreichen Teraview inzwischen Anfragen zur THz-Analyse, wie etwa in der Dentaltechnik, Lackschichten in der Automobilproduktion oder zur Detektion von Rissen und Schichtablösungen bei Keramiken.

BioPhotonik 1/2012













For more information see
http://www.photonik.de/biopl/98/3/0/228/3d-tablettenpruefung-mittels-terahertz.html

For help with your pharmaceutical problems also see
http://www.teraview.com/services/applications-support/index.html

Properties of InxGa1−xN films in terahertz range

A. Gauthier-Brun^1,2, J. H. Teng¹, E. Dogheche², W. Liu¹, A. Gokarna², M. Tonouchi³, S. J. Chua¹, and D. Decoster²

¹Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 3 Research link, Singapore 117602, Singapore
²Institute of Electronics, Microelectronics and Nanotechnology, UMR-CNRS 8520, Avenue Poincaré, 59652 Villeneuve d’Ascq Cedex, France
³Institute of Laser Engineering, Osaka University, 2-6 Yamada-Oka, Suita-City, Osaka 565-0871, Japan                         

Abstract
In this letter, we report the characterization of the refractive indices and complex conductivities of a set of GaN films with different carrier concentrations, InN film, and In_xGa_1−xN films with indium content varying from x = 0.07 to x = 0.14 grown by metalorganic chemical vapor deposition for frequencies ranging from 0.3 to 3 THz using terahertz time-domain spectroscopy (THz-TDS). The refractive indices of In_xGa_1−xN films at THz range are reported. The carrier density and mobility determined using THz-TDS method show good agreement with four-probe Hall measurements.

Appl. Phys. Lett. 100, 071913 (2012)

for more information click here

The data was obtained using TeraView's Spectra 3000.

"The THz- TDS data are obtained using a TeraView Spectra 3000 system, in which the THz wave is generated by focusing a mode-locked Ti:sapphire laser beam with a wavelength of 800 nm and pulse width of 100 fs onto a low temperature- grown GaAs photoconductive ..."

Dielectric Properties of Monoclonal Antibodies to Influenza Using Terahertz Spectroscopy

From the Proceedings of 2011 International Conference on Opto-Electronics Engineering and Information Science (ICOEIS 2011)


Abstract. In this paper we use terahertz spectroscopy to study the effects of the monoclonal antibody to influenza A and the monoclonal antibody to influenza B. The complex permittivity was measured over the frequency range 0.1-1.7 THz.
The investigated antibodies can be distinguished by the frequency dependence of the dielectric properties. Therefore terahertz spectroscopy may be useful for medical diagnoses where the presence of antibodies is indicative of disease.


...TPI Imaga 1000 (TeraView Limited, Cambridge, UK) was used to determine the
terahertz 1535 Page 2. dielectric response...


http://www.asaas.org/ICOEIS2011/N361.pdf

TeraView at the International Forum on Terahertz Spectroscopy and Imaging - March 2012

TeraView will have a table top at the International Forum on Terahertz Spectroscopy and Imaging at Fraunhofer-Zentrum, Kaiserlautern (Germany)

http://www.teraview.com/news/terahertz-events/index.html

Come and visit us!

To organise a meeting please e-mail David Lowe

International Forum 
on Terahertz Spectroscopy and Imaging

Nowadays Terahertz technology has proven to be a valuable tool for applications in diagnostics, measurement and testing. The industrial use of this technology, however, puts a lot of challenging questions.

The following renowned experts in the field of Terahertz Technology have con­firmed invited to give invited lectures to the forum:

• Prof. Dr. Daniel M. Mittleman, Rice University, USA
• Prof. Dr. Peter Uhd Jepsen, Technical University of Denmark, Denmark
• Prof. Dr. Koichiro Tanaka, Kyoto University, Japan

Scope:

The workshop refers to users, developers and manufacturers of THz measurement systems. The fifth workshop will address primarily the topics

1.        Nondestructive Testing

2.        Technology for Homeland Security

3.        New Technologies

4.        Health and Social Aspects of Terahertz Technology

TeraView hiring for summer intern job - Technical Marketing

TeraView is seeking a Physics or Electronic Engineering undergraduate/recent graduate, for a temporary position (10-12 weeks). The role is primarily focused on technical marketing, with the incumbent working with various sources to generate leads whilst also supporting the various electronic marketing media.

For more information on this position visit our website on:
http://www.teraview.com/terahertz/about/careers-jobs.html

TeraView expands U.S. presence in Dayton

UK-based TeraView, the world’s first company devoted to the application of Terahertz (THz) light for imaging and spectroscopy, opened its first overseas office in Dayton last year. Fresh from raising $5.5 million of new investment, the company is now expanding their facility in the Institute for the Development and Commercialization of Advanced Sensor Technology (IDCAST) to offer contract analytical services to U.S. pharmaceutical companies. From 1^st March, a TPI Imaga 2000 tablet imaging system will be available for demonstrations or rental and adds strength to the existing spectroscopy and imaging capability within IDCAST. The company also plans, in conjunction with IDCAST, to run a series of terahertz workshop aimed at showing how terahertz can be best used in pharmaceutical development..

“There is an impressive concentration of Terahertz systems and technology in this region,” said TeraView CEO Don Arnone last March. “Our long and productive associations with world-class researchers in this region, who we support and work with as collaborators and customers, make Ohio ideally suited for this facility.” TeraView has worked with scientists at Miami University, Ohio State, and Wright State, among others, and are eager to establish new collaborations with other institutions.

TeraView’s proprietary platform uses the THz spectrum between light and radio waves and offers the advantage of being non-invasive and non-destructive. Past studies have demonstrated how THz uniquely and non destructively provides chemical and 3D structural information in a diverse range of applications, including the contents of drug tablets, and other objects normally invisible to conventional detection techniques.

According to Sr. VP Sales and Marketing Ian Grundy, the company is moving more of their own equipment into rented IDCAST space and wants to expand contract analysis services. “Our contract analysis product gives pharma companies access to Terahertz technology and data to develop new products or help resolve quality issues, particularly at scale-up,” he said.

In conjunction with UK institutions, using a proprietary terahertz probe TeraView also has conducted in-vivo trials on the detection of various cancers using a THz probe. Work has been primarily done on skin and breast cancers. The results to-date have shown good specificity and selectivity. The company has also supplied its medical probe system to other researchers and is actively looking to expand its collaborations in the area.

Prediction of dissolution time and coating thickness of sustained release formulations using Raman spectroscopy and terahertz pulsed imaging

·         European Journal of Pharmaceutics and Biopharmaceutics

Available online 5 January 2012

• Joshua Müller^a, 
• Daniela Brock^a, 
• Klaus Knop^a, 
• J. Axel Zeitler^b, 
• Peter Kleinebudde

• Abstract

  Raman spectroscopy was implemented successfully as a non-invasive and rapid process analytical technology (PAT) tool for in-line quantitative monitoring of functional coating. Coating experiments were performed at which diprophylline tablets were coated with a sustained release formulation based on Kollicoat® SR 30 D. Using PLS a multivariate model was constructed by correlating Raman spectral data with the mean dissolution time as determined by dissolution testing and the coating thickness as measured by terahertz pulsed imaging.
  By performing in-line measurements it was possible to monitor the progress of the coating process and to detect the end point of the process, where the acquired coating amount was achieved for the desired MDT or coating thickness.
  
  Mean dissolution time (MDT) over coating time predicted by Raman spectroscopy (top left) and in correlation to coating thickness measured by terahertz spectroscopy (top right). Layer thickness maps and histograms from TPI measurements after a short (left) and a longer (right) coating time.
  
  
  Terahertz results were acquired on a TeraView's TPI2000 instrument.
  
  
  For more information :
  http://www.sciencedirect.com/science/article/pii/S0939641111003614
  
  

  Keywords

  • Process analytical technology; 
  • Multivariate data analysis; 
  • Raman spectroscopy; 
  • Terahertz pulsed imaging; 
  • Functional coating; 
  • Mean dissolution time
  
  

Structures and characterization of m-nisoldipine polymorphs - CrystEngComm (RSC Publishing)

Structures and characterization of m-nisoldipine polymorphs - CrystEngComm (RSC Publishing)

Structures and characterization of m-nisoldipine polymorphs

Paper

Caiqin Yang ,  Zhenwei Zhang ,  Yanli Zeng ,  Jing Wang ,  Yongli Wang and Baoqing Ma

CrystEngComm, 2012, Advance Article

DOI: 10.1039/C2CE06359J

http://pubs.rsc.org/en/content/articlelanding/2012/ce/c2ce06359j


Abstract

m-Nisoldipine, a dihydropyridine calcium ion antagonist, first synthesized in the School of Pharmaceutical Sciences, Hebei Medical University, exhibits two polymorphs A and B with different colors and morphologies. The single-crystal X-ray structure analysis reveals that polymorph A crystallizes in a monoclinic P2₁/c space group with a = 9.3045(2) Å, b = 16.5991(5) Å, c = 13.0018(3) Å, β = 91.539(2)° and Z = 4, while B crystallizes in a triclinic space group of P1 with a = 7.4965(2) Å, b = 11.4692(4) Å, c = 12.3648(5) Å, α = 68.093(2)°, β = 88.655(2)°, γ = 81.853(2)° and Z = 2. The m-nisoldipine molecules are connected through N–H....O hydrogen bonds between the carbonyl group and the amine group to form either a wavy chain for A or a linear chain for B. The two polymorphs show distinct physicochemical properties as characterized by IR, Raman, DSC and terahertz pulse spectroscopy. DFT theoretical calculations are also used to simulate the terahertz spectroscopy of the two polymorphs.

for more information about  the Spectra 3000 spectrometer click here

(http://www.teraview.com/products/terahertz-pulsed-spectra-3000/index.html)

TeraView listed among companies that dominate EU fundraising in January

TeraView mentioned in this article from http://blogs.ft.com about where investment has been dominant during January!


Cambridge-based TeraView, which makes solutions based on Terahertz technology, raised $5.5m from  New Hill Management and Full Circle Investments in the US,  YFM Equity Partners and Turquoise International in the UK and other investors. Turquoise International invested on behalf of the UK Low Carbon Innovation Fund.


http://blogs.ft.com/fttechhub/2012/01/internet-companies-dominate-eu-fundraising-in-january/#ixzz1l8yDWuWa