Monday, 20 April 2020

Dual-band refractometric terahertz biosensing with intense wave-matter-overlap microfluidic channel

Lan, Feng, Feng Luo, Pinaki Mazumder, Ziqiang Yang, Lin Meng, Zhengqiang Bao, Jun Zhou et al. "Dual-band refractometric terahertz biosensing with intense wave-matter-overlap microfluidic channel." Biomedical optics express 10, no. 8 (2019): 3789-3799.

Abstract

We theoretically and experimentally demonstrate a label-free terahertz biosensor with ultrahigh sensitivity and distinctive discretion. By constructing a metal-air-metal (MAM) metamaterial perfect absorber (MPA) with a metallic paired-ring resonator array, a hollow microfluidic channel, and a backed reflector, a novel dual-band absorptive sensing platform is proposed in the THz range. The near field coupling by dipole-induced trapped modes and the magnetic momentum caused a vertical to transverse power flux that dramatically enhanced the electromagnetic field on top of the metasurface and in the microfluidic channel, respectively. Both the resonant modes exhibit perfect absorption and produce ultrahigh normalized sensitivities of 0.47/RIU (refractive index unit, RIU) and 0.51/RIU at 0.76 THz and 1.28 THz, respectively. Compared with conventional microfluidic sensors, the salient advantages of our design are the perfect spatial overlap for light-matter interaction and polarization insensitivity. Characterized by THz time domain spectroscopic absorption quantification measurements with different concentrations of bovine serum albumin (BSA), the proposed sensor exhibits promising applications in microfluidic biosensing.

for full paper see https://www.osapublishing.org/DirectPDFAccess/E5A68527-E751-58C9-0EA1FAFBC1FCF41A_415013/boe-10-8-3789.pdf?da=1&id=415013&seq=0&mobile=no 


… The TDS modeled as TPS Spectra 3000 from TeraView, which supplies full access to 0.06-4 THz spectral region with 0.006 THz resolution and 80 dB dynamic range. The simulation and experimental results are shown in Fig. 7(d) and (e), respectively …

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