Friday, 12 September 2014

Terahertz time-domain spectroscopy for measurement of particle sizes of fexofenadine hydrochloride

Anna Sadloňová, Vojtech Kresalek, Tomas Bata

Abstract

Time domain spectroscopy is one of the new methods of terahertz radiation used for wide spectrum of the industry. More extended sector is the security system much like the sector of the medicine. The main focus is orientated to detection and identification of the substances. This study is focused on the measurement of the particle size of pharmaceuticals. The characteristic absorption features will be studied experimentally by Terahertz time-domain spectroscopy. The results are identified for processing by one of the statistical method usable for such variable groups. The three samples of the pharmaceutical– Fexofenadine Hydrochloride (antihistamine) will be compared between themselves. Mentioned samples are supplied by different suppliers. The main focus will be put on the pharmaceutical differences of the same pharmaceutical that are commonly available on the markets. Terahertz time-domain spectroscopy setup was used to measure absorbance spectra of each sample in the range from 1 THz to 3 THz (it was used the device TPS Spectra 3000 produced by TeraView Ltd . The device that belongs to the first commercial machine developed in this company for measurement of the substances by transmission spectroscopy method.). During the testing was used the vacuum for purging the measurement chamber from water vapors.

This study was performed using TeraView's Spectra 3000 system. (TeraView, Cambridge, UK)