Abstract
Time domain spectroscopy is one of the new methods of terahertz
radiation used for wide spectrum of the industry. More extended sector is the
security system much like the sector of the medicine. The main focus is
orientated to detection and identification of the substances. This study is
focused on the measurement of the particle size of pharmaceuticals. The
characteristic absorption features will be studied experimentally by Terahertz
time-domain spectroscopy. The results are identified for processing by one of
the statistical method usable for such variable groups. The three samples of
the pharmaceutical– Fexofenadine Hydrochloride (antihistamine) will be compared
between themselves. Mentioned samples are supplied by different suppliers. The
main focus will be put on the pharmaceutical differences of the same
pharmaceutical that are commonly available on the markets. Terahertz
time-domain spectroscopy setup was used to measure absorbance spectra of each
sample in the range from 1 THz to 3 THz (it was used the device TPS Spectra
3000 produced by TeraView Ltd . The device that belongs to the first commercial
machine developed in this company for measurement of the substances by
transmission spectroscopy method.). During the testing was used the vacuum for
purging the measurement chamber from water vapors.
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