University of California, San Diego Uses TeraView's Instrument for Near-field Microscopy

Cambridge, UK – 27th November, 2012

TeraView, the pioneer and leader in terahertz solutions and technology, has successfully delivered a TPS Spectra 3000 system to the Infrared Laboratory for Novel Infrared and Magnetic Materials at the University of California, San Diego, founded and let by Professor Dimitri Basov.

Professor Basov and his laboratory are world leaders in the use of optical and infrared methods to investigate the characteristic energies and physics of strongly correlated electron systems, magnetic semiconductors, superconductivity and other novel electromagnetic materials.  Prof Basov’s team will utilize the system for both routine characterisation of material systems at low temperatures, as well as a new project to develop a near-field microscopy system utilising terahertz time-domain techniques for spectroscopic measurements in ultra-high vacuum. TeraView has supplied a special breadboard version of its TPS Spectra 3000 time-domain terahertz spectrometer for the project.

Professor Basov is chair of the Department of Physics at the University of California at San Diego and has a long and substantive track record in the use of terahertz, infrared and optical methods applied to fundamental studies in condensed matter physics. He is a recipient of numerous prizes, including most recently the Frank Isakson Prize for Optical Effects in Solids from the American Physical Society in 2012.

This new project adds to TeraView’s growing installed base in the United States, and helps strengthen its position as the market leader for terahertz systems. Dr Don Arnone, TeraView’s CEO stated: ‘This collaboration with a prestigious research group highlights TeraView’s position as major supplier of terahertz systems and indicates the continued growth in the use of terahertz as a valuable tool for both fundamental physics as well as applications development in exciting areas such as terahertz microscopy'.

Validation of Terahertz Coating Thickness Measurements Using X-ray Microtomography

Isabelle-Sophie Russe †‡, Daniela Brock †‡, Klaus Knop ‡, Peter Kleinebudde ‡, and J. Axel Zeitler *†

^† Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, U.K.

^‡ Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitätsstrasse 1, 40225 Düsseldorf, Germany

Mol. Pharmaceutics, DOI: 10.1021/mp300383y Publication Date (Web): November 1, 2012

Abstact

Terahertz pulsed imaging (TPI) is a recently developed nondestructive and noncontact method to measure the coating thickness of coated pharmaceutical tablets. The method requires no calibration in order to resolve the coating structure of tablets. The relative coating thickness over a tablet surface or between different tablets of the same batch can be determined with high precision. However, in order to determine the absolute coating thickness accurately the refractive index, n, of the coating layer needs to be known. For all published studies to date the value of n was based on estimates or bulk measurements, which were based on the assumption that n is constant for a given coating formulation. We have developed a measurement technique using X-ray microtomography to independently quantify the coating thickness. These data were then used to validate the terahertz imaging results, and we found that the intertablet variation of n for coating layers of 25–270 μm thickness is less than 4% and that there is less than 3% intratablet variation in n. Based on our results we estimate that, depending on the pigment content, the absolute value of n in a typical pharmaceutical coating formulation will be in the range of 1.45 < n < 2.01. We conclude that TPI is a robust technique and that, due to its very simple measurement principle, it is an ideal measurement technique to quantify the coating thickness in process control and quality monitoring applications.

To learn more about TeraView see http://www.teraview.com/applications/pharmaceutical/index.html

Terahertz spectroscopy in the pseudo-Kagome system Cu3Bi(SeO3)2O2Br

THz spectroscopy in the pseudo-Kagome system Cu3Bi(SeO3)2O2Br

Zhe Wang, M. Schmidt, Y. Goncharov, V. Tsurkan, H.-A. Krug von Nidda, A. Loidl, J. Deisenhofer

(Submitted on 4 Oct 2012 (v1), last revised 13 Nov 2012 (this version, v2))

Terahertz (THz) transmission spectra have been measured as function of temperature and magnetic field on single crystals of Cu3Bi(SeO3)2O2Br. In the time-domain THz spectra without magnetic field, two resonance absorptions are observed below the magnetic ordering temperature T_N~27.4 K. The corresponding resonance frequencies increase with decreasing temperature and reach energies of 1.28 and 1.23 meV at 3.5 K. Multi-frequency electron spin resonance transmission spectra as a function of applied magnetic field show the field dependence of four magnetic resonance modes, which can be modeled as a ferromagnetic resonance including demagnetization and anisotropy effects.

View full article http://arxiv.org/pdf/1210.1343v2.pdf

.......Time-domain THz transmission measurements were carried out on a 2 × 2 × 0.3 mm3 single crystal for 3.5 K <T < 300 K using a TPS spectra 3000 spectrometer with f/2 focusing optics (TeraView, Ltd.). ...

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For more information about the Spectra 3000 used for these measurements see http://www.teraview.com/products/index.html

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Complex THz Reflectance Spectra of Hexogen Measured for Various Surfaces

N. Palka

Institute of Optoelectronics, Military University of Technology S. Kaliskiego 2, 00-908 Warsaw, Poland

ACTA PHYSICA POLONICA A 122, 854-7 (2012)

Abstract

In this paper, we report on measurements of reflection spectra of hexogen (RDX) by means of time domain spectroscopy. We analyzed both phase and amplitude of reflected impulses for three cases: detuning, samples with rough surfaces and samples with curved surfaces. It can be concluded that both spectral characteristics can be applied for identification of explosives in the reflection configuration.

For full paper see http://przyrbwn.icm.edu.pl/APP/PDF/122/a122z5p16.pdf

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For more information about the Spectra 3000 used for these measurements see http://www.teraview.com/products/terahertz-pulsed-spectra-3000/terahertz-standoff-detection.html
 
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Terahertz Spectra of Explosives Measured by Optical Parametric Oscillator-Based System and Time Domain Spectroscopy

N. Palka, T. Trzcinski and M. Szustakowski
Institute of Optoelectronics, Military University of Technology, S. Kaliskiego 2, 00-908 Warsaw, Poland

ACTA PHYSICA POLONICA A, 122, 946 (2012)

Abstact

In this paper, we report on measurements of absorption spectra of hexogen, penthrite, and octogen. The measurements were carried out by means of time domain spectroscopy and compared to spectra obtained from a setup, which bases on an optical parametric oscillator combined with a Golay cell. For time domain spectroscopy measurement, Teraview TPS 3000 unit with accessories in transmission con figuration was used.


"TDS is a commonly used technique in THz range to measure transmission spectra of materials. In our measurements we used a commercially available spectrometer TPS 3000 from TeraView."

for full paper see http://przyrbwn.icm.edu.pl/APP/PDF/122/a122z5p16.pdf


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FINANCIAL ACE QUITS TAPTU FOR TERAVIEW

TeraView, the Cambridge UK pioneer in terahertz solutions and technology, has appointed a new chief financial officer as it steps up its global growth strategy.

Lynsey Wilson is a senior level finance executive with over 15 years finance and accounting experience focused on the management of technology-based SME’s.

She joins Teraview from Taptu, where as CFO she was involved in the sale of the company to RSS ad giant Mediafed.

Bruce Anderson, the current chief financial officer, is staying on with TeraView as a senior adviser.

Dr Don Arnone, TeraView CEO said: “Lynsey’s extensive financial experience across a number of innovative technology companies will clearly enhance TeraView’s management team.

“We are excited to welcome Lynsey and she will be a great asset to our future growth strategy. We also wish to take this opportunity to thank Bruce for his commitment to the company and his substantial contribution to its commercial progress over the past several years.”

TeraView was recently cleared by regulators to start trials of a world-first, hand-held breast cancer probe. With support from the Technology Strategy Board (TSB) and in collaboration with surgeons at Guy’s Hospital in London, TeraView has developed the device as part of the world’s first commercial terahertz medical unit.

In January, the company secured $5.5m of investment from a consortium of US, Asian and EU based institutional and corporate investors.

TeraView markets itself as the world’s first company devoted to the application of Terahertz light for spectroscopy and imaging. A spin out from Toshiba and Cambridge University in 2001 and employing circa 25 staff, TeraView has been developing the technology across a number of areas and applications and now has equipment in over 20 countries.

Headquartered in Cambridge, TeraView offers sales and support throughout Europe, North America and the Far East either directly or through a network of distributors.

Key Laboratories in France Select TeraView

TeraView, the pioneer and leader in terahertz solutions and technology, has been chosen to supply systems to the Georgia Tech-CNRS laboratory in Metz and the LOMA laboratory at the University of Bordeaux 1. The systems were selected due to their superior performance, ease of use and the Company’s track record with its existing customers.

A TPS Spectra 3000 system will be located at Georgia-Tech Lorraine in the Georgia Tech-CNRS Unité Mixte Internationale 2958, an international joint laboratory between the Georgia Institute of Technology and the French Centre National de la Recherche Scientifique (CNRS). Professor David Citrin is in charge of the laboratory and brings a wealth of experience and knowledge of terahertz physics in imaging and non-destructive testing of various materials.

The second TPS Spectra 3000 system will be delivered to the Laboratoire Ondes et Matière d'Aquitaine (LOMA), a joined research unit of the University of Bordeaux 1 and CNRS. Professor Patrick Mounaix, who is the director of research at the Short Laser Applications and Materials (SLAM) group at LOMA, will utilize the system for postal inspection and othermaterials characterisation requirements. His expertise in terahertz imaging and time-domain spectroscopy has delivered significant contribution to the research of THz applications in solid state physics. 

These sales strengthen TeraView’s links with world-leading THz researchers and key opinion leaders. ‘The addition of two premier French laboratories, with truly international reach, to our list of collaborators is an exciting opportunity to enhance the Company’s technology footprint across Europe and beyond ’ said Dr Don Arnone, TeraView CEO. The sales add to the Company’s growing base of clients and helps strengthen its position as the market leader for terahertz systems.

For more information about the Spectra 3000 visit http://www.teraview.com/products/terahertz-pulsed-spectra-3000/index.html

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Optimizing multi-dimensional terahertz imaging analysis for colon cancer diagnosis

Expert Systems with Applications

Available online 16 October 2012

Leila H. Eadie
Centre for Computational Intelligence, De Montfort University, The Gateway, Leicester, UK; Centre for Rural Health, Aberdeen University, Centre for Health Science, Old Perth Road, Inverness, UK

Abstract

Terahertz reflection imaging (at frequencies ∼0.1–10 THz/10¹²Hz) is non-ionizing and has potential as a medical imaging technique; however, there is currently no consensus on the optimum imaging parameters to use and the procedure for data analysis. This may be holding back the progress of the technique. This article describes the use of various intelligent analysis methods to choose relevant imaging parameters and optimize the processing of terahertz data in the diagnosis of ex vivo colon cancer samples. Decision trees were used to find important parameters, and neural networks and support vector machines were used to classify the terahertz data as indicating normal or abnormal samples. This work reanalyzes the data described in Reid et al. (Physics in Medicine and Biology, 2011, 56, 4333–4353), and improves on their reported diagnostic accuracy, finding sensitivities of 90–100% and specificities of 86–90%. This optimization of the analysis of terahertz data allows certain recommendations to be suggested concerning terahertz reflection imaging of colon cancer samples.

for full paper see http://www.sciencedirect.com/science/article/pii/S0957417412011335

... One or more normal and diseased samples were taken from each patient. The samples were imaged using a stand-alone portable THz system, the TPIimaga1000 (TeraViewLtd, Cambridge, UK) in reflection mode. Full details of the system can be found in Wallace et al. (2004). ...

For more information about the Spectra 3000 visit http://www.teraview.com/products/terahertz-pulsed-spectra-3000/index.html

Efficiency of using correlation function for estimation of probability of substance detection on the base of THz spectral dynamics

Vyacheslav A. Trofimov ; Nikolay V. Peskov ; Dmitry A. Kirillov

Proc. SPIE 8496, Terahertz Emitters, Receivers, and Applications III, 84960T (October 15, 2012); doi:10.1117/12.927441Text Size: A A A

From Conference Volume 8496

Terahertz Emitters, Receivers, and Applications III

San Diego, California, USA | August 12, 2012

Abstract

One of the problems arising in Time-Domain THz spectroscopy for the problem of security is the developing the criteria for assessment of probability for the detection and identification of the explosive and drugs. We analyze the efficiency of using the correlation function and another functional (more exactly, spectral norm) for this aim. ........

For full abstract see http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1380697

... For Time Domain Spectroscopy measurement the TeraView TPS 3000 unit with two accessories designed for the reflection was used [19].  ...

For more information about the Spectra 3000 visit http://www.teraview.com/products/terahertz-pulsed-spectra-3000/index.html

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Terahertz imaging on subcutaneous tissues and liver inflamed by liver cancer cells

Terahertz Science and Technology, ISSN 1941-7411 Vol. 5, No. 3, September 2012

C. H. Zhang 1, 4, G. F. Zhao 2, B. B. Jin 1*, Y. Y. Hou 2*, H. H. Jia 3, J. Chen 1 and P. H. Wu 1*

1 Research Institute of Superconductor Electronics (RISE), School of Electronic Science and Engineering, Nanjing

University, Nanjing 210093, China

2 Immunology and Reproductive Biology Lab, Medical School & State Key Laboratory of Pharmaceutical

Biotechnology, Nanjing University, Nanjing, 210093, China

3 Currently National University of Defense Technology, Changsha, 410008, China

4 Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, Japan

*1 Email: bbjin@nju.edu.cn, *2 yayihou@nju.edu.cn & *1 phwu@nju.edu.cn

Abstract: 
Terahertz (THz) imaging has a number of potential applications in medical imaging and diagnosis. Here,we demonstrate the THz images on the diseased and the corresponding normal tissues from 14 samples. The liver cancer cells are planted by subcutaneous injection into BALB/c which share high degree homology with human.  Subcutaneous tumors and nearby normal tissues as well as the inflamed livers and normal liver tissues are achieved after 7 days, 14 days and 21 days injection. Terahertz time-domain spectroscopy (TDS) is used to image these tissues.  We have found that at certain frequency range, most tumors and serious inflamed livers have lower absorption that normal tissues, which mean THz imaging could obviously distinguish the tumors and normal tissues, serious inflamed and normal livers, but could not obviously distinguish the grade of tumors and inflammation.

... into slices. The size of slice is about 26 mm×20 mm×1.5 mm. 3. Experimental procedure In this study, all measurements are completed with a transmitted TDS imaging system (TPI Image 1000, TeraView Ltd, UK). A mode-locked ...

For more information about the Spectra 3000 visit http://www.teraview.com/products/terahertz-pulsed-spectra-3000/index.html

Terahertz and mid-infrared spectroscopy of benzene-1,2-diol

Journal of Molecular Spectroscopy

Available online 2 October 2012

ZP Zheng, WH Fan, H Yan, J Liu, WZ Yang, SL Zhu 

State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China

Abstract

The terahertz (8-128 cm^-1) and mid-infrared spectra (400-2000 cm^-1) of benzene-1,2-diol at room temperature were measured by using terahertz time-domain spectroscopy and Fourier transform infrared spectroscopy, respectively. Comparing the experimental terahertz and mid-infrared spectra with computed results by density functional theory, we find that all the terahertz spectral features come from inter-molecular vibrations, and the mid-infrared spectral features mainly originate from intra-molecular vibrations, although inter-molecular vibrations still make the contributions in some extent.

The terahertz (THz) and mid-infrared (MIR) spectra of benzene-1,2-diol in the solid state have been modeled by density functional theory (DFT). Calculations of the vibrational spectra based on the optimized geometries provided a good fit to the observed spectra, and a more reasonable spectral reproduction has been achieved than those in previous work. For THz spectrum, the simulation based on the varied unit cell dimension has clearly shown that THz spectral reproduction is affected by the temperature change of unit cell. For MIR spectrum, band assignments are reported in terms of potential-energy distribution (PED), which differ to those previously reported for benzene-1,2-diol in some respects.

... Experimentally, THz spectrum (8-128 cm -1 ) of benzene-1,2-diol was measured by using TPS
spectra 3000 (TeraView Limited) with the spectral resolution of 1.2 cm -1 . MIR spectrum....

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