Wednesday, 10 October 2012

Terahertz imaging on subcutaneous tissues and liver inflamed by liver cancer cells

Terahertz Science and Technology, ISSN 1941-7411 Vol. 5, No. 3, September 2012

C. H. Zhang 1, 4, G. F. Zhao 2, B. B. Jin 1*, Y. Y. Hou 2*, H. H. Jia 3, J. Chen 1 and P. H. Wu 1*
1 Research Institute of Superconductor Electronics (RISE), School of Electronic Science and Engineering, Nanjing
University, Nanjing 210093, China
2 Immunology and Reproductive Biology Lab, Medical School & State Key Laboratory of Pharmaceutical
Biotechnology, Nanjing University, Nanjing, 210093, China
3 Currently National University of Defense Technology, Changsha, 410008, China
4 Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, Japan
*1 Email:, *2 & *1

Terahertz (THz) imaging has a number of potential applications in medical imaging and diagnosis. Here,we demonstrate the THz images on the diseased and the corresponding normal tissues from 14 samples. The liver cancer cells are planted by subcutaneous injection into BALB/c which share high degree homology with human.  Subcutaneous tumors and nearby normal tissues as well as the inflamed livers and normal liver tissues are achieved after 7 days, 14 days and 21 days injection. Terahertz time-domain spectroscopy (TDS) is used to image these tissues.  We have found that at certain frequency range, most tumors and serious inflamed livers have lower absorption that normal tissues, which mean THz imaging could obviously distinguish the tumors and normal tissues, serious inflamed and normal livers, but could not obviously distinguish the grade of tumors and inflammation.

TPS Spectra 300

... into slices. The size of slice is about 26 mm×20 mm×1.5 mm. 3. Experimental procedure In this study, all measurements are completed with a transmitted TDS imaging system (TPI Image 1000, TeraView Ltd, UK). A mode-locked ...