Presentation at IFPAC 2018

Dissolution Modeling of a Controlled Release Osmotic Tablet using Terahertz Pulsed Imaging (TPI): A Chemometric Approach 

Zach Dance1, Brian Regler1, Donna Carroll1, Busolo Wabuyele1, Jerry Klinzing1, Jim DiNunzio1, Gary Chia1, Lee Dowden1, Gerard Bredael1, David Harris1, Zhihao Lin1, Phil Taday2

[1Merck & Co., Inc., 2TeraView Ltd.]

see https://www.xcdsystem.com/IFPAC/program/sEg2Mf6/index.cfm

Abstract: 

Push-pull osmotic tablets are currently being developed for controlled release of compound A in order to provide once daily dosing. The release rate of compound A from the osmotic tablet has been found to be largely controlled by the coating thickness. Terahertz pulsed imaging (TPI) uses short pulses of terahertz radiation (2-120 cm-1) that penetrate typical pharmaceutical components. The time delay of reflections of these pulses from materials of different refractive indexes in the sample allows for the measurement of thickness of various materials. Using TPI, the coating thickness of compound A osmotic tablets can be measured in a rapid, non-destructive manner across an entire tablet. The coating thickness data obtained using TPI was found to be in line with other analysis techniques such as XRCT. Combining the dissolution release rate data from products designed to provide different drug release rates through modification of coating weight, a chemometric model was developed to predict release rate as a function of coating thickness.

For more information: TeraView