Hope T. Beier, Air Force Research Lab.; Benjamin P. Born, Weizmann Institute of Science (Israel); Patrick O. Bradshaw, Air Force Office of Scientific Research; Elliott R. Brown, Wright State Univ.; Ibtissam Echchgadda, National Academy of Sciences;Yuri Feldman, The Hebrew Univ. of Jerusalem (Israel); Martina Havenith, Ruhr-Univ. Bochum (Germany); Peter Uhd Jepsen, Technical Univ. of Denmark (Denmark); Kodo Kawase, RIKEN (Japan); Martin Koch, Technische Univ. Braunschweig (Germany);Richard Nuccitelli, BioElectroMed Corp.; Gun-Sik Park, Seoul National Univ. (Korea, Republic of); Emma Pickwell-MacPherson, Hong Kong Univ. of Science and Technology (Hong Kong, China); W. Pat Roach, Air Force Research Lab.; Peter H. Siegel, Jet Propulsion Lab.; Joo-Hiuk Son, The Univ. of Seoul (Korea, Republic of); Koichiro Tanaka, Kyoto Univ. (Japan); Robert J. Thomas, Air Force Research Lab.; P. Thomas Vernier, The Univ. of Southern California; Shu Xiao, Old Dominion Univ.
The terahertz (THz) region of the electromagnetic (EM) spectrum is defined as frequencies ranging from 0.1 to 10 THz (1 THz = 1012 Hz = 1 ps). Historically, few sources have been available to efficiently generate THz radiation; however, several recent technological advances have resulted in the unprecedented development of many new types of THz sources and components. These technologies are now being used as tools for a plethora of novel basic science investigations, and they are increasingly being integrated into innovative sensing and imaging operational schemes, which are finding widespread use in a host of medical, military, and defense applications.
Ultrashort electromagnetic pulses (USEP) are defined as pulses with duration below one microsecond and a rise time at or below a nanosecond. Direct application of USEP on tissue has been shown to elicit an array of biological effects including plasma membrane breakdown, cellular swelling, nuclear granulation, and initiation of apoptotic death. These observed phenomena have spawned quick advancement of USEP-based techniques into clinical devices to treat both superficial and deep cancers. USEP-based technologies have a distinct advantage of causing desired effects only within the profile of the electric field with little to no thermal footprint. Future technology is pushing beyond direct application into shorter pulse regimes (picoseconds) to enable free field propagation of USEP into deep tissue. These efforts have required advancements in pulse generators and antenna construction. The drive to shorter pulse duration bridges the gap between electrical pulses and those commonly generated by THz sources.
Fundamental knowledge gaps exist regarding how electric fields with frequency components from the MHz to the THz interact with biological structures. This conference aims to highlight USEP and THz source development, biological applications, and fundamental interactions with tissues, cells, and biomolecules. Scientific papers that push the state-of-the-art are solicited. These include:
Basic Science and Phenomenology: interaction mechanisms, biological effects, and molecular dynamics
THz time-domain spectroscopy (THz-TDS): transmission, reflection, KITA, and attenuated total reflection (ATR)
Biological effects of THz radiation and USEP at organism, tissue, cellular, and biomolecular level
Molecular dynamics in meso-space: water relaxation components, hydration and biosolvation dynamics
Biomedical Diagnostics and Therapeutics: Imaging, Spectroscopy, and Multi-modality approaches
Cancer diagnosis and margin detection: skin, breast, liver, and oral tissues