Exploring the Robustness of Terahertz-Based at-Line Porosity Measurements for Realising a Non-Destructive Dissolution Assay of Tablets during Manufacturing

Bawuah, Prince, Daniel Markl, Daniel Farrell, Mike Evans, Alessia Portieri, Andrew Anderson, Daniel Goodwin, Ralph Lucas, and Axel Zeitler. "Exploring the Robustness of Terahertz-Based at-Line Porosity Measurements for Realising a Non-Destructive Dissolution Assay of Tablets during Manufacturing." In 2019 AIChE Annual Meeting. AIChE, 2019.

INTRODUCTION

To achieve a continuous downstream manufacturing process with in-process quality monitoring and real-time release testing capabilities, different process analytical technologies (PATs) such as laser scattering methods, near infrared (NIR) spectroscopy, and Raman spectroscopy can be deployed to, for example, measure the particle size of raw materials and powder blends as well as to detect the content uniformity of powder blends and tablets. However, the use of the above-mentioned PAT methods to directly measure and quantify the bulk properties of tablets, e.g. porosity, that govern the mass transport processes and mechanical changes in tablets during disintegration and dissolution, are limited. For example, NIR methods to quantify tablet hardness typically probes surface properties only and these measurements are not necessarily..........

For full paper see https://www.aiche.org/conferences/aiche-annual-meeting/2019/proceeding/paper/260f-exploring-robustness-terahertz-based-line-porosity-measurements-realising-non-destructive

"Terahertz time-domain measurements of all the batches were acquired using a TeraPulse 4000 (TeraView Ltd., Cambridge, UK). The porosity was extracted from the measured terahertz effective refractive index using Bruggeman's effective medium theory [1,5]."