Zarrella, Salvatore, Elena Wanvig i Dot, J. Axel Zeitler, and Timothy M. Korter. "From powder to spectrum: A tutorial of terahertz transmission time-domain spectroscopy." International Journal of Pharmaceutics (2026): 126586.
Abstract
Terahertz time-domain spectroscopy (THz-TDS) is a non-destructive, high-resolution method that probes low-frequency vibrational modes and intermolecular interactions between the microwave and infrared regions inaccessible by other spectroscopic methods. The technique is established in the pharmaceutical sciences and is now spreading to other areas in need of an extensive understanding of material properties. Despite the growth in THz applications, measurements are still confined to specialized laboratories. This tutorial seeks to provide a practical standard operating procedure for taking transmission measurements of compacted powders and is designed for new users across disciplines. We describe sample preparation, spectrometer configuration, data acquisition, signal processing, quantitative analysis, and troubleshooting. Emphasis is placed on practical strategies such as selecting appropriate diluents, ensuring homogeneous sample mixing, optimizing pellet thickness, aligning the optical setup, and handling spectral artifacts like Fabry–Pérot etalons. Additionally, the tutorial guides users through data transformation using FFT and apodization techniques to extract accurate optical constants such as refractive index and absorption coefficients. By consolidating best practices and minimizing technical barriers, this resource aims to make THz spectroscopy more accessible and reproducible for researchers across disciplines.
see https://www.sciencedirect.com/science/article/pii/S0378517326000347
No comments:
Post a Comment