Application of Terahertz Pulsed Imaging to Assess the Film Coating Characteristics of Sustained-Release Coated Pellets

University of Otago, TeraView, and Université Lille Nord de France present at the 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Application of Terahertz Pulsed Imaging to Assess the Film Coating Characteristics of Sustained-Release Coated Pellets

Miriam Haaser, Youness Karrout, Carine Velghe, Yvonne Cuppok, Keith C. Gordon, Michael Pepper, Jürgen Siepmann, Clare J. Strachan, Philip F. Taday, Thomas Rades

School of Pharmacy, Department of Chemistry and MacDiarmid Institute for Advanced Materials and Nanotechnology, University of Otago, Dunedin, New Zealand

TeraView Limited, Cambridge, United Kingdom

Cavendish Laboratory, University of Cambridge, Cambridge , United Kingdom

College of Pharmacy, Université Lille Nord de France, Lille, France

Department of Electronic Engineering, University College London, London, United Kingdom

Abstract

Terahertz pulsed imaging (TPI) was employed for the first time to explore its suitability for detecting differences in the coating thickness and internal characteristics of standard size pellets (1 mm in diameter).  Furthermore, the effect of coating characteristics on the subsequent drug release behaviour of the pellets was investigated.

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