Terahertz pulsed imaging study to assess remineralization of artificial caries lesions (J. Biomed. Opt. 16, 026001)

David Churchley and Richard J. M. Lynch

GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, KT13 0DE, United Kingdom

Frank Lippert and Jennifer Susan O’Bryan Eder

Indiana University School of Dentistry, Oral Heath Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202

Jesse Alton

TeraView Ltd, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, United Kingdom

Carlos Gonzalez-Cabezas

University of Michigan, School of Dentistry, 1011 N. University B305, Ann Arbor, Michigan 48109–1078

Abstract

We compare terahertz–pulsed imaging (TPI) with transverse microradiography (TMR) and microindentation to measure remineralization of artificial caries lesions. Lesions are formed in bovine enamel using a solution of 0.1 M lactic acid/0.2% Carbopol C907 and 50% saturated with hydroxyapatite adjusted to pH 5.0. The 20-day experimental protocol consists of four 1 min treatment periods with dentifrices containing 10, 675, 1385, and 2700 ppm fluoride, a 4-h∕day acid challenge, and, for the remaining time, specimens are stored in a 50:50 pooled human∕artificial saliva mixture. Each specimen is imaged at the focal point of the terahertz beam (data-point spacing = 50 μm).........

For more information see http://dx.doi.org/10.1117/1.3540277

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