Characterisation of amorphous and crystalline domains using terahertz spectroscopy

M.E. Marlow², H. Seker ² and G. Smith¹
1 School of Pharmacy and 2Centre for Computational Intelligence, +De Montfort University Leicester (DMU), UK,
3 School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK

Introduction

The centre portion of the terahertz region has a unique combination of properties in that: many amorphous excipients are transparent or semi-transparent to terahertz radiation whilst many crystalline materials have characteristic spectral features. The research presented here is focused on developing methods for characterising crystalline and amorphous domains in drug products. A model system of tablets comprised of either Avicel® PH-101 or polyethylene (PE) (both transparent to terahertz) with lactose monohydrate have been used to evaluate terahertz spectroscopy methods in the transmission and reflection modes.

More info at: https://www.dora.dmu.ac.uk/xmlui/handle/2086/7930

... For both transmission and reflection  measurements the time domain signal was recorded using  the TeraView TPI 3000 (TeraView, Cambridge, UK). Terahertz images were obtained by raster scanning the  terahertz beam across the sample ...